• Ronald Natale on Treatment Options for EGFR-Mutant Lung Cancer
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    Ronald Natale on Treatment Options for EGFR-Mutant Lung Cancer

    There’s no question that ultimately patients with EGFR-mutated lung cancer will have disease that will become refractory to all treatments. And so we don’t yet have curative therapy. We are actively looking at immunotherapy in these patients. I think immunotherapy offers a strategy to treat them, either after EGFR/TKI treatment or after EGFR/TKI followed by chemotherapy, which would be my preferred approach. These patients have a response to immunotherapy that is a little bit lower than the general unselected patient population. Hopefully we’ll have biomarkers that will allow us to better select patients for immunotherapy, but that’s still a work in progress. So I try to be frank with my…

  • Discovering What Cosmetics To Use During And After Cancer Treatments
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    Discovering What Cosmetics To Use During And After Cancer Treatments

    I’m really happy to be here tonight. Thank you all for coming. I have, often, people ask me why I went into this specialty. Number one, I like helping people. And number two, an increasing number of my clients were being diagnosed with cancer. And I wanted to learn how to treat them safely. So I went back to school and got certified. And that began my journey. So I’m here to share my knowledge and experience with you in your journey. And hopefully, you’ll get some things that are useful tonight. OK, the four things that I deal with mostly with clients with cancer– these are the four conditions…

  • “Skin Cancer Can Hit Even YOU!?”
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    “Skin Cancer Can Hit Even YOU!?”

    It’s May…It’s Another Sultry Summer In South Fla.! hey gang it’s Paul back again I have a lot of wonderful things to talk to you about but this is kind of just the filling I think I can’t believe that we’ve been off the air for a few weeks now ever since our initial foray into life under the palms I think it was going well but it’s very difficult to to have Brad balance a really taxing job that gives him a not much relaxation and I kind of said can we do can we do a film today can we do a film today place it next for…

  • Skin Cancer Survivors Not Practicing Safe Sun
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    Skin Cancer Survivors Not Practicing Safe Sun

    Melanoma survivors do not always protect their skin from sun damage. I’m Erin White and this is a dailyRx Minute. More than 25 percent of melanoma survivors don’t use sunscreen when they’re in the sun for more than an hour. And more than 2 percent of people who’ve lived through melanoma still use sun tanning beds. This year, an estimated 77,000 Americans will be diagnosed with melanoma, the deadliest form of skin cancer. Ask your doctor how to protect your skin from sun damage. For dailyRx TV, I’m Erin White.

  • Two Dimensions in Targeting HER2
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    Two Dimensions in Targeting HER2

    Two Dimensions in Targeting HER2 HER2 and HER3 receptors and their motive activation through dimerization and activation of PI3k/Akt signaling and binding sites of trastuzumab, pertuzumab, and lapatinib. HER2 is a receptor tyrosine kinase located at the cell membrane with a large extracellular domain (ECD) and an intracellular catalytic kinase domain (KD) and signaling tail. Signal generation by HER2 occurs through heterodimerization with its HER family siblings. The activated HER2 KD then phosphorylates the c-tail of HER3, leading to recruitment of several proteins and initiating a series of parallel signaling cascades that ultimately execute the phenotypic changes in cell behavior. In HER2-driven cancer cells, it also regulates HER3 in a…

  • Health Topics: Skin Cancer
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    Health Topics: Skin Cancer

    Sun. It’s the sun damage, and as the sun damage we’ve had as kids. My patients will always ask me: ‘does that mean I don’t need to wear sunscreen anymore?’ and the answer to that is no, you still need to wear sunscreen. You know because the damage can still happen. It’s mostly from the sun damage there are some genetic abnormalities that we have it that we’ve been born with that predispose us to not be able to repair the damage that we get from our environment. Most people it’s just from the sun. Patients that have had a lesion that they’ve had since childhood, sometimes we’re not as…